Functional Genomics of the -Cell: Short-Chain 3- Hydroxyacyl-Coenzyme A Dehydrogenase Regulates Insulin Secretion Independent of K Currents
نویسندگان
چکیده
Departments of Genetics (O.T.H., R.K.G., P.W., K.H.K.) and Biochemistry and Biophysics (N.M.D., F.M.M.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology and Cancer Biology and Medicine (H.E.H., T.C.B., C.B.N.), Duke University Medical Center, Durham, North Carolina 27704; and Computational Biology and Informatics Laboratory (E.M., C.J.S.), University of Pennsylvania, Philadelphia, Pennsylvania 19104
منابع مشابه
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
Recent advances in functional genomics afford the opportunity to interrogate the expression profiles of thousands of genes simultaneously and examine the function of these genes in a high-throughput manner. In this study, we describe a rational and efficient approach to identifying novel regulators of insulin secretion by the pancreatic beta-cell. Computational analysis of expression profiles o...
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